Welcome to the
Human PNS Atlas
A large-scale single-cell transcriptional and spatial atlas of human peripheral nerves in health and disease (polyneuropathies). Interactive visualizations of the snRNA-seq and Xenium spatial transcriptomics data are available below.
Publication — Multi-omic identification of perineurial hyperplasia and lipid-associated nerve macrophages in human polyneuropathies, Heming et al., Nature Communications, 2025
Code — GitHub | archived on Zenodo
Raw data — GEO GSE285983 | GSE285984
Reproducibility — Quarto document with automatic data download from Zenodo
Datasets
Single nuclei sural nerve atlas (365,708 nuclei) of 33 polyneuropathy patients and 4 controls
Spatial transcriptomics (Xenium) of a sural nerve from a patient suffering from CIAP (chronic idiopathic axonal polyneuropathy) (S14).
Spatial transcriptomics (Xenium) of a healthy human sural nerve (S24).
Spatial transcriptomics (Xenium) of a a sural nerve from a patient suffering from VN (vasculitic neuropathy) (S30).
Spatial transcriptomics (Xenium) of a sural nerve from a patient suffering from CIDP (chronic inflammatory demyelinating polyneuropathy) (S01).
Contact
If you have any questions, please contact us via mheming.com.